Evidence of linkage to 6p23 and genetic heterogeneity in nonsyndromic cleft lip with or without cleft palate.

@article{Scapoli1997EvidenceOL,
  title={Evidence of linkage to 6p23 and genetic heterogeneity in nonsyndromic cleft lip with or without cleft palate.},
  author={Luca Scapoli and Furio Pezzetti and Francesco Carinci and Marcella Martinelli and Paolo Carinci and Mauro Tognon},
  journal={Genomics},
  year={1997},
  volume={43 2},
  pages={216-20}
}
Nonsyndromic cleft lip with or without cleft palate (CL+/-P) is a congenital orofacial anomaly that derives from an embryopathy with failure of nasal process and palatal shelves fusion. CL+/-P is one of the most common malformations, affecting 1/700-1/1000 live births among Caucasians. Early investigations have suggested that a clefting gene may be located on the short arm of chromosome 6 (6p), as well as in other regions. In this study, we analyzed a large sample of families by using eight PCR… CONTINUE READING