Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease

@article{Roberts2010EvidenceOI,
  title={Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease},
  author={Rebecca Roberts and Ruth K G Topless and Amanda J Phipps-Green and R B Gearry and Murray Lindsay Barclay and Tony Raymond Merriman},
  journal={Genes and Immunity},
  year={2010},
  volume={11},
  pages={351-356}
}
The location of CARD8 within an inflammatory bowel disease (IBD) locus and its role in the NALP3 inflammasome and as a nuclear factor (NF)κB inhibitor make it an attractive candidate risk gene for IBD. However, studies testing for the association of the CARD8 loss-of-function single-nucleotide polymorphism (SNP) rs2043211 with IBD have yielded mixed results. A recent study provided evidence that this discordance may result from an interaction of rs2043211 with loss-of-function variants in… CONTINUE READING
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