Evidence of independent gene duplications during the evolution of archaeal and eukaryotic family B DNA polymerases.

@article{Edgell1998EvidenceOI,
  title={Evidence of independent gene duplications during the evolution of archaeal and eukaryotic family B DNA polymerases.},
  author={David R. Edgell and Saad Bashir Malik and W. Ford Doolittle},
  journal={Molecular biology and evolution},
  year={1998},
  volume={15 9},
  pages={1207-17}
}
Eukaryotes and archaea both possess multiple genes coding for family B DNA polymerases. In animals and fungi, three family B DNA polymerases, alpha, delta, and epsilon, are responsible for replication of nuclear DNA. We used a PCR-based approach to amplify and sequence phylogenetically conserved regions of these three DNA polymerases from Giardia intestinalis and Trichomonas vaginalis, representatives of early-diverging eukaryotic lineages. Phylogenetic analysis of eukaryotic and archaeal… CONTINUE READING

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