Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study

  title={Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study},
  author={Julie C. Price and David E. Kelley and Christopher M. Ryan and Carolyn C. Meltzer and Wayne C. Drevets and Chester A. Mathis and Sati Mazumdar and Charles F. Reynolds},
  journal={Brain Research},

Age, Sex, and Reproductive Hormone Effects on Brain Serotonin-1A and Serotonin-2A Receptor Binding in a Healthy Population

Endocrine standardization minimized confounding introduced by endogenous hormonal fluctuations and reproductive stage and permitted us to detect small effects of sex, age, and endogenous sex steroid exposures upon 5HT1A binding.

PET tracers for 5-HT(1A) receptors and uses thereof.

Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-11C]WAY-100635—considerations on the validity of cerebellum as a reference region

Exceptionally high uptake of [carbonyl-11C]WAY-100635 in the gray matter of cerebellum in one healthy male subject, which was reproducible in repeated PET scanning and most likely represents specific binding to 5-HT1A receptors in cerebellar gray matter.

Diabetes Attenuates the Antidepressant-Like Effect Mediated by the Activation of 5-HT1A Receptor in the Mouse Tail Suspension Test

The results suggest that the antidepressant-like effect mediated by 5-HT1A receptors may be attenuated by diabetes.

Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome

  • C. Gragnoli
  • Biology, Medicine
    The application of clinical genetics
  • 2014
Depression, type 2 diabetes (T2D), and metabolic syndrome (MetS) are often comorbid. Depression per se increases the risk for T2D by 60%. This risk is not accounted for by the use of antidepressant

Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications

This study shows that cognitive efficiency may decline over time in diabetic adults, and that this neurocognitive change may be linked, at least in part, to the occurrence of complications like proliferative retinopathy and elevated blood pressure.

Why is cognitive dysfunction associated with the development of diabetes early in life? The diathesis hypothesis

  • C. Ryan
  • Medicine, Psychology
    Pediatric diabetes
  • 2006
This review describes a vulnerability hypothesis and posit that in the very young child diagnosed with diabetes, chronic hyperglycemia initiates a cascade of structural and functional changes within the central nervous system that disrupt normal brain development and those individuals with diabetes who have this cerebral vulnerability will show the greatest degree of neurocognitive impairment.



Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.

Binding potential values were reduced across many of the regions examined, including frontal, temporal, and limbic cortex in both unmedicated and medicated depressed patients compared with healthy volunteers.

Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions

  • R. ParseyM. Slifstein M. Laruelle
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
In conclusion, derivation of BP by kinetic analysis using the arterial plasma input function appeared as the method of choice because of its higher test—retest reproducibility, lower vulnerability to experimental noise, and absence of bias.

Cerebral complications of diabetes: clinical findings and pathogenetic mechanisms.

  • G. Biessels
  • Medicine, Psychology
    The Netherlands journal of medicine
  • 1999