Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study

@article{Price2002EvidenceOI,
  title={Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study},
  author={Julie C. Price and David E. Kelley and Christopher M. Ryan and Carolyn C. Meltzer and Wayne C. Drevets and Chester A. Mathis and Sati Mazumdar and Charles F. Reynolds},
  journal={Brain Research},
  year={2002},
  volume={927},
  pages={97-103}
}

Age, Sex, and Reproductive Hormone Effects on Brain Serotonin-1A and Serotonin-2A Receptor Binding in a Healthy Population

Endocrine standardization minimized confounding introduced by endogenous hormonal fluctuations and reproductive stage and permitted us to detect small effects of sex, age, and endogenous sex steroid exposures upon 5HT1A binding.

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  • Medicine, Psychology
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References

SHOWING 1-10 OF 52 REFERENCES

Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.

Binding potential values were reduced across many of the regions examined, including frontal, temporal, and limbic cortex in both unmedicated and medicated depressed patients compared with healthy volunteers.

Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions

  • R. ParseyM. Slifstein M. Laruelle
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
In conclusion, derivation of BP by kinetic analysis using the arterial plasma input function appeared as the method of choice because of its higher test—retest reproducibility, lower vulnerability to experimental noise, and absence of bias.

Cerebral complications of diabetes: clinical findings and pathogenetic mechanisms.

  • G. Biessels
  • Medicine, Psychology
    The Netherlands journal of medicine
  • 1999
...