Evidence of increased association of fibrinogen with platelets caused by sodium citrate.

Washed platelet suspensions are almost always prepared from blood anticoagulated with sodium citrate. Because citrate has been reported to affect platelet function, we examined the involvement of citrate on the platelet-fibrinogen interactions. More iodine 125-labeled fibrinogen was bound on washed platelets from citrate-anticoagulated blood (CP) than on… CONTINUE READING