Evidence of in vivo basophil activation in chronic idiopathic urticaria.

  title={Evidence of in vivo basophil activation in chronic idiopathic urticaria.},
  author={Kavitha Vasagar and Becky M. Vonakis and Laura M Gober and Ann Viksman and Scott P. Gibbons and S S Saini},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={36 6},
BACKGROUND Approximately 40% of chronic idiopathic urticaria (CIU) subjects have autoantibodies to either FcepsilonRIalpha or IgE. The effect of such autoantibodies on circulating basophil activation status is unknown. OBJECTIVE The expression of cell surface activation markers on basophils from CIU, non-allergic, and allergic subjects were compared. Further, the relationship between marker expression and serum factors reported in CIU, such as histamine-releasing activity (HRA) and… CONTINUE READING


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