Evidence of genetic progression in human gastric carcinomas with microsatellite instability

@article{Chung1997EvidenceOG,
  title={Evidence of genetic progression in human gastric carcinomas with microsatellite instability},
  author={Yeun-Jun Chung and Sang-Won Park and Ji-Min Song and Kyo-young Lee and Eun-Joo Seo and Sang-Wook Choi and Mun-Gan Rhyu},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={1719-1726}
}
Mutator phenotype tumors provide unique opportunities to unravel malignant progression because of various gene alterations acquired during clonal tumor evolution. Gastric carcinomas, which have been known to show frequent genetic instability, would be composed of initial gene alterations shared by most tumor areas and subsequent alterations restricted to particular tumor sites. To analyse the timing of genetic events, we examined separate sites of tumor tissue obtained from a given gastric… CONTINUE READING
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