Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells.

@article{Chang2009EvidenceOG,
  title={Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells.},
  author={Piek Ngoh Chang and Wei Ney Yap and Davy Tak Wing Lee and M T Ling and Yong Chuan Wong and Yee Leng Yap},
  journal={Nutrition and cancer},
  year={2009},
  volume={61 3},
  pages={357-66}
}
To date, the most effective cure for metastatic melanoma remains the surgical resection of the primary tumor. Recently, tocotrienol-rich-fraction has shown antiproliferative effect on cancer cells. To elucidate this anticancer property in malignant melanoma, this study aimed, first, to identify the most potent isomer for eliminating melanoma cells and second to decipher the molecular pathway responsible for its activity. Results showed that the inhibitory effect of gamma-tocotrienol was most… CONTINUE READING

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