Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP).

@article{Lutz2002EvidenceOF,
  title={Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP).},
  author={Christina Lutz and Johannes Nimpf and Marcel Jenny and Karl Boecklinger and Christiane Enzinger and Gerd Utermann and Gabriele Baier-Bitterlich and Gottfried Baier},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 45},
  pages={
          43143-51
        }
}
Lipoprotein receptors, such as LRP, have been shown to assemble multiprotein complexes containing intracellular signaling molecules; however, in vivo, their signaling function is poorly understood. Using a novel LRP receptor fusion construct, a type I transmembrane protein chimera, termed sIgG-LRP (bearing the intracellular COOH-terminal tail of human LRP as recombinant fusion to a transmembrane region plus the extracellular IgG-F(c) domain), we here investigated LRP signal transduction… CONTINUE READING
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