Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver.

@article{Mattsson2004EvidenceOF,
  title={Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver.},
  author={G{\"o}ran Mattsson and Leif Jansson and Astrid Nordin and A. -S. Andersson and Per-Ola Carlsson},
  journal={Diabetes},
  year={2004},
  volume={53 4},
  pages={948-54}
}
A drawback in pancreatic islet transplantation is the large number of islets needed to obtain insulin independence in patients with diabetes. This most likely reflects extensive posttransplantation islet cell death and functional impairment of the remaining endocrine cells. We aimed to develop an experimental method to retrieve transplanted islets from the mouse liver, which would enable comparisons of transplanted and endogenous islets and provide valuable information on functional changes… CONTINUE READING
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