Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy).

@article{Oaklander2006EvidenceOF,
  title={Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy).},
  author={Anne louise Oaklander and Julia G Rissmiller and Lisa B Gelman and Li Zheng and Yuchiao Chang and Ralph Gott},
  journal={Pain},
  year={2006},
  volume={120 3},
  pages={235-43}
}
CRPS-I consists of post-traumatic limb pain and autonomic abnormalities that continue despite apparent healing of inciting injuries. The cause of symptoms is unknown and objective findings are few, making diagnosis and treatment controversial, and research difficult. We tested the hypotheses that CRPS-I is caused by persistent minimal distal nerve injury (MDNI), specifically distal degeneration of small-diameter axons. These subserve pain and autonomic function. We studied 18 adults with IASP… CONTINUE READING
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