Evidence of elevated intracellular calcium levels in weaver homozygote mice.

  title={Evidence of elevated intracellular calcium levels in weaver homozygote mice.},
  author={Amy B. Harkins and Stephen R. Dlouhy and Bernardino Ghetti and Anne L. Cahill and Lisa Won and Barbara Heller and Alfred Heller and Aaron P. Fox},
  journal={The Journal of physiology},
  volume={524 Pt 2},
1. A mutation in the G-protein-linked, inwardly rectifying K+ channel GIRK2 leads to the loss of cerebellar and dopaminergic mesencephalic neurons in weaver mice. The steps leading to cell death are not well understood but may involve constitutive influx of Na+ and Ca2+ into the neurons. 2. We found that resting [Ca2+]i was dramatically higher in cerebellar neurons from weaver mice compared to wild-type neurons. 3. High-K+ stimuli elicited much smaller changes in [Ca2+]i in weaver cerebellar… CONTINUE READING
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