Evidence of efficient stop codon readthrough in four mammalian genes

  title={Evidence of efficient stop codon readthrough in four mammalian genes},
  author={Gary Loughran and M Chou and Ivaylo P. Ivanov and Irwin Jungreis and Manolis Kellis and Anmol M. Kiran and Pavel V. Baranov and John F. Atkins},
  booktitle={Nucleic acids research},
Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes had been reported. Analysis of conserved protein coding signatures that extend beyond annotated stop codons identified potential stop codon readthrough of four mammalian genes. Here we use a modified targeted bioinformatic approach to identify a further three mammalian readthrough candidates. All seven… CONTINUE READING
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