Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.

@article{Perkins2009EvidenceOD,
  title={Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.},
  author={Brittany R Perkins and Julia Chamot-Rooke and Sung Hwan Yoon and Ashley C Gucinski and Arp{\'a}d Somogyi and Vicki H. Wysocki},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 48},
  pages={
          17528-9
        }
}
Peptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure. IRMPD spectroscopy combined with computational modeling and gas-phase H/D exchange was used to study the structure of the b(2)(+) ion from protonated HAAAA. The experimental spectrum of the b(2)(+) ion matches both the experimental spectrum for the protonated cyclic dipeptide HA (a commercial diketopiperazine) and the theoretical spectrum for a diketopiperazine protonated at the imidazole pi nitrogen. A… CONTINUE READING

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