Evidence of clinically significant extravascular stores of factor IX.

@article{Feng2013EvidenceOC,
  title={Evidence of clinically significant extravascular stores of factor IX.},
  author={David H Feng and Kimberlee A. Stafford and George J. Broze and Darrel W. Stafford},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 12},
  pages={2176-8}
}
Coagulation factor IX (FIX) is a plasma protein whose absence results in hemophilia B, a disease ameliorated by injection of FIX. The pharmacokinetics of infused FIX are complicated. Of injected FIX, 50–80% disappears within 5 min [1–3]. Furthermore, Briet has observed that FIX injected into patients with hemophilia B lacking antigen disappears more rapidly than FIX injected into patients with normal levels of inactive FIX [4]. Furthermore, in patients with hemophilia B who receive continuous… CONTINUE READING