Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells

@article{Cleary2002EvidenceOC,
  title={Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells},
  author={John Douglas Cleary and Kerrie Nichol and Yuh-Hwa Wang and Christopher E. Pearson},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={37-46}
}
The mechanism of disease-associated trinucleotide repeat instability involves cis-acting factors (cis-elements) in the vicinity of the repeat, but the nature of these elements is unknown. One cis-element may be the location of the replication origin relative to the repeat. We have used an SV40 DNA replication system to investigate the effect of the location of replication initiation on (CTG)n•(CAG)n stability in primate cells. Depending on the distance between the SV40 replication origin and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

conformations at the fork

  • L. Postow, N. J. Crisona, B. J. Peter, C. D. Hardy, Cozzarelli, N. R. Topological challenges to DNA replication
  • Proc. Natl Acad. Sci. USA 98, 8219–8226
  • 2001

unraveling trinucleotide repeat diseases

  • C. J. Cummings, Zoghbi, H. Y. Fourteen, counting
  • Hum. Mol. Genet. 9, 909–916
  • 2000

Similar Papers

Loading similar papers…