Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis.

@article{Clment2005EvidenceOA,
  title={Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis.},
  author={Sophie Cl{\'e}ment and Pierre Vaudaux and Patrice François and Jacques Schrenzel and Elzbieta Huggler and Sandy Kampf and Christine Chaponnier and Daniel Lew and J D Lacroix},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={192 6},
  pages={1023-8}
}
Severe infections due to Staphylococcus aureus require prolonged therapy for cure, and relapse may occur even years after the first episode. Persistence of S. aureus may be explained, in part, by nasal carriage of S. aureus, which occurs in a large percentage of healthy humans and represents a major source of systemic infection. However, the persistence of internalized S. aureus within mucosal cells has not been evaluated in humans. Here, we provide the first in vivo evidence of intracellular… CONTINUE READING