Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence.

@article{Orte2008EvidenceOA,
  title={Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence.},
  author={Angel Orte and Timothy D Craggs and Samuel S. White and Sophie E. Jackson and David Klenerman},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 25},
  pages={7898-907}
}
Determining how proteins fold into their native structures is a subject of great importance, since ultimately it will allow protein structure and function to be predicted from primary sequence data. In addition, there is now a clear link between protein unfolding and misfolding events and many disease states. However, since proteins fold over rugged, multidimensional energy landscapes, this is a challenging experimental and theoretical problem. Single-molecule fluorescence methods developed… CONTINUE READING