Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents.

@article{Reinehr2008EvidenceOA,
  title={Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents.},
  author={Thomas Reinehr and Anke Hinney and Trang T. Nguyen and Johannes Hebebrand},
  journal={Diabetes},
  year={2008},
  volume={57 3},
  pages={623-6}
}
OBJECTIVE Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located approximately 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese. The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype. RESEARCH DESIGN AND METHODS We genotyped rs7566605 in 293 obese children (mean age 10.8 years, 45% male, mean BMI 28… CONTINUE READING

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Long-term follow-up of cardiovascular risk factors in obese children after intervention

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