Evidence of altered neurogranin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex.

@article{Broadbelt2006EvidenceOA,
  title={Evidence of altered neurogranin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex.},
  author={Kevin Broadbelt and Andrew Ramprasaud and Liesl B. Jones},
  journal={Schizophrenia research},
  year={2006},
  volume={87 1-3},
  pages={6-14}
}
Schizophrenia is a complex and poorly understood neuropsychiatric disorder. Much research has begun to implicate the prefrontal cortex in the disease. Using immunocytochemistry we determined if neurogranin, a protein found in dendrites, spines and cell bodies and an upstream regulator of calcium was altered in areas 9 and 32 of schizophrenic prefrontal cortex. We examined its expression in pyramidal cells in layers III and V. Tissues from 7 controls and 7 schizophrenics (from our original MAP2… CONTINUE READING

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