Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.

@article{GarcaBueno2016EvidenceOA,
  title={Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.},
  author={Borja Garc{\'i}a-Bueno and Patricia Gass{\'o} and Karina S Macdowell and Luis F Callado and Sergi Mas and Miquel Bernardo and Amalia Lafuente and J Javier Meana and Juan Carlos Leza},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={2016},
  volume={41 3},
  pages={E46-55}
}
BACKGROUND Alterations in the innate immune/inflammatory system may underlie the pathophysiology of schizophrenia, but we do not understand the mechanisms involved. The main agents of innate immunity are the Toll-like receptors (TLRs), which detect molecular patterns associated with damage and pathogens. The TLR first reported was TLR4, and it is still the most studied one. METHODS We aimed to describe putative modifications to the TLR4 proinflammatory pathway using 2 different strategies in… CONTINUE READING
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