Evidence of abundant purifying selection in humans for recently acquired regulatory functions.

@article{Ward2012EvidenceOA,
  title={Evidence of abundant purifying selection in humans for recently acquired regulatory functions.},
  author={Lucas D. Ward and Manolis Kellis},
  journal={Science},
  year={2012},
  volume={337 6102},
  pages={1675-8}
}
Although only 5% of the human genome is conserved across mammals, a substantially larger portion is biochemically active, raising the question of whether the additional elements evolve neutrally or confer a lineage-specific fitness advantage. To address this question, we integrate human variation information from the 1000 Genomes Project and activity data from the ENCODE Project. A broad range of transcribed and regulatory nonconserved elements show decreased human diversity, suggesting lineage… CONTINUE READING
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