Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response.

@article{Thomas2002EvidenceOA,
  title={Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response.},
  author={Celestine J. Thomas and M. L. Kapoor and Shilpi Sharma and Huguette Bausinger and Umit Zyilan and Dan Lipsker and Daniel Hanau and Avadhesha Surolia},
  journal={FEBS letters},
  year={2002},
  volume={531 2},
  pages={184-8}
}
The kinetics of the interaction of lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP) and CD14 was studied using surface plasmon resonance. The association and dissociation rate constants for the binding of LPS and rsCD14 were 2.9 x 10(4) M(-1) s(-1) and 0.07 s(-1) respectively, yielding a binding constant of 4.2 x 10(5) M(-1). Significantly… CONTINUE READING