Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.


Antizyme and its endogenous antizyme inhibitor have recently emerged as prominent regulators of cell growth, transformation, centrosome duplication, and tumorigenesis. Antizyme was originally isolated as a negative modulator of the enzyme ornithine decarboxylase (ODC), an essential component of the polyamine biosynthetic pathway. Antizyme binds ODC and… (More)
DOI: 10.1158/1541-7786.MCR-11-0178


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