Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.

@article{Bektas1999EvidenceOA,
  title={Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.},
  author={Arsun Bektas and M E Suprenant and Lewis T. Wogan and Nattachet Plengvidhya and Stephen S. Rich and James H. Warram and Andrzej S Krolewski and Alessandro Doria},
  journal={Diabetes},
  year={1999},
  volume={48 11},
  pages={
          2246-51
        }
}
To replicate the recent finding of a type 2 diabetes locus (NIDDM2) on 12q, families segregating early-onset autosomal-dominant type 2 diabetes were screened for linkage. Included were 26 Caucasian and 6 non-Caucasian pedigrees with an average age at diabetes diagnosis of 37 +/- 18 years. Affected (n = 233) and nonaffected (n = 152) family members were genotyped for 17 markers covering 90 cM on chromosome 12q. While no evidence for linkage was detected at the NIDDM2 locus, a linkage peak was… CONTINUE READING

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