Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children.

@article{Esper2005EvidenceOA,
  title={Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children.},
  author={Frank L. Esper and Carla Weibel and David Ferguson and Marie Louise Landry and Jeffrey S Kahn},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={191 4},
  pages={492-8}
}
BACKGROUND The etiological agents responsible for a substantial proportion of respiratory tract diseases have not been identified. We sought to determine whether novel human coronaviruses (HCoVs) are circulating in New Haven, Connecticut, and, if so, whether they are associated with respiratory tract disease in infants and young children. METHODS We developed a polymerase chain reaction (PCR)-based approach for screening specimens from the respiratory tracts of symptomatic children. PCR… CONTINUE READING

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