Evidence of a non-conventional role for the urokinase tripartite complex (uPAR/uPA/PAI-1) in myogenic cell fusion.

@article{Bonavaud1997EvidenceOA,
  title={Evidence of a non-conventional role for the urokinase tripartite complex (uPAR/uPA/PAI-1) in myogenic cell fusion.},
  author={Sylvie Bonavaud and Cecile Charriere-Bertrand and Catherine Rey and Marie Pierre Leibovitch and Nina Marie Pedersen and Eric Frisdal and Emmanuelle Planus and Francesco Domenico Di Blasi and RomainK. Gherardi and Georgia Barlovatz-Meimon},
  journal={Journal of cell science},
  year={1997},
  volume={110 ( Pt 9)},
  pages={
          1083-9
        }
}
Urokinase can form a tripartite complex binding urokinase receptor (uPAR) and plasminogen activator inhibitor type-1 (PAI-1), a component of the extracellular matrix (ECM). The components of the tripartite complex are modulated throughout the in vitro myogenic differentiation process. A series of experiments aimed at elucidating the role of the urokinase tripartite complex in the fusion of human myogenic cells were performed in vitro. Myogenic cell fusion was associated with increased cell… CONTINUE READING

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