Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype

@article{Barsky1997EvidenceOA,
  title={Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype},
  author={Sanford H. Barsky and Mark D. Sternlicht and Suzi Safarians and Mai Linh Nguyen and Koei Chin and Sophia D Stewart and Alan L. Hiti and Joe W. Gray},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={2077-2091}
}
The highly metastatic amelanotic C8161 human melanoma line was found to exhibit complete dominance of its undifferentiated and metastatic phenotype in multiple somatic cell hybridization studies designed to bypass the presence of potential tumor suppressor genes. In a three armed approach involving somatic cell fusions of C8161 with recipient lines of greater differentiation, different lineage, and different tumorigenicity status, the metastatic and undifferentiated phenotype of C8161 was… CONTINUE READING