Evidence of a Pro-Arrhythmic Substrate in the Failing Right Ventricle of Pulmonary Hypertensive Rats

@inproceedings{Benoist2010EvidenceOA,
  title={Evidence of a Pro-Arrhythmic Substrate in the Failing Right Ventricle of Pulmonary Hypertensive Rats},
  author={David Benoist and Rachel Stones and Olivier Bernus and Mark J. Drinkhill and Ed White},
  year={2010}
}
Arrhythmic risk is increased in patients with heart failure. We have investigated the arrhythmic state of the failing right ventricle in a model of pulmonary hypertension (PAH).Wistar rats were injected intraperitoneally with monocrotaline (MCT, 60 mg/kg) to induce PAH and right ventricular failure within 3-4 weeks and compared to age-matched saline-injected animals (CON).In vivo measurement of ECG parameters using radiotelemetry indicated modification of T wave-parameters in MCT treated… CONTINUE READING