Evidence of a M1-muscarinic GPCR homolog in unicellular eukaryotes: featuring Acanthamoeba spp bioinformatics 3D-modelling and experimentations

  title={Evidence of a M1-muscarinic GPCR homolog in unicellular eukaryotes: featuring Acanthamoeba spp bioinformatics 3D-modelling and experimentations},
  author={Abdul Mannan Baig and Hakimuddin Razi Ahmad},
  journal={Journal of Receptors and Signal Transduction},
  pages={267 - 275}
  • A. BaigH. R. Ahmad
  • Published 4 May 2017
  • Biology
  • Journal of Receptors and Signal Transduction
Abstract Acetylcholine affects the target cellular function via muscarinic and nicotinic cholinergic receptors that are seen to exist in humans. Both the cholinergic receptors are G-protein coupled receptors (GPCRs) that perform cardinal functions in humans. Anti-muscarinic drugs, particularly the ones that target M1 subtype (mAChR1), have consistently shown to kill unicellular pathogenic eukaryotes like Acanthamoeba spp. As the M1 receptor subtype has not been reported to be expressed in the… 

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