Evidence of a M1-muscarinic GPCR homolog in unicellular eukaryotes: featuring Acanthamoeba spp bioinformatics 3D-modelling and experimentations

@article{Baig2017EvidenceOA,
  title={Evidence of a M1-muscarinic GPCR homolog in unicellular eukaryotes: featuring Acanthamoeba spp bioinformatics 3D-modelling and experimentations},
  author={A. M. Baig and H. Ahmad},
  journal={Journal of Receptors and Signal Transduction},
  year={2017},
  volume={37},
  pages={267 - 275}
}
  • A. M. Baig, H. Ahmad
  • Published 2017
  • Biology, Medicine
  • Journal of Receptors and Signal Transduction
  • Abstract Acetylcholine affects the target cellular function via muscarinic and nicotinic cholinergic receptors that are seen to exist in humans. Both the cholinergic receptors are G-protein coupled receptors (GPCRs) that perform cardinal functions in humans. Anti-muscarinic drugs, particularly the ones that target M1 subtype (mAChR1), have consistently shown to kill unicellular pathogenic eukaryotes like Acanthamoeba spp. As the M1 receptor subtype has not been reported to be expressed in the… CONTINUE READING
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    References

    SHOWING 1-10 OF 28 REFERENCES
    Two types of muscarinic acetylcholine receptors in Drosophila and other arthropods
    • 30
    Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
    • 163
    RpkA, a Highly Conserved GPCR with a Lipid Kinase Domain, Has a Role in Phagocytosis and Anti-Bacterial Defense
    • 21
    • PDF
    Monoclonal antibodies detect the conservation of muscarinic cholinergic receptor structure from Drosophila to human brain and detect possible structural homology with alpha 1-adrenergic receptors.
    • 78
    • PDF
    In Vitro Efficacies of Clinically Available Drugs against Growth and Viability of an Acanthamoeba castellanii Keratitis Isolate Belonging to the T4 Genotype
    • 36
    • PDF
    Allosteric activation of the CaR by L-amino acids.
    • B. Kobilka
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 18
    • PDF
    Muscarinic receptor agonists and antagonists: effects on cancer.
    • E. Spindel
    • Biology, Medicine
    • Handbook of experimental pharmacology
    • 2012
    • 144
    The Phyre2 web portal for protein modeling, prediction and analysis
    • 4,686
    • PDF