Evidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients

  title={Evidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients},
  author={Xueling Zhu and Xiang Wang and Jin Xiao and Jian Liao and Shuqiao Yao},
  journal={Biological Psychiatry},
Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients
It is suggested that depressed people have altered DMN patterns during implicit emotional processing, which might be related to impaired internal monitoring and emotional regulation ability.
Dissociation of regional activity in the default mode network in first-episode, drug-naive major depressive disorder at rest.
Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression
Resting-State Functional Connectivity of Antero-Medial Prefrontal Cortex Sub-Regions in Major Depression and Relationship to Emotional Intelligence
It is suggested that individuals with depression have reduced FC between antero-medial PFC regions and regions involved in emotional regulation compared to control subjects, and vmPFC functional connectivity appears linked to emotional intelligence.
First-Episode Medication-Naive Major Depressive Disorder Is Associated with Altered Resting Brain Function in the Affective Network
Reduced ALFF in the OFC suggests hypo-functioning of emotion regulation in the affective network, which may reflect dysfunction of the amygdala-OFC network and additionally represent a pathological process of MDD.


Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects
It is demonstrated that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.
Investigating neural primacy in Major Depressive Disorder: Multivariate granger causality analysis of resting-state fMRI time-series data
It is shown that, on a moment-by-moment basis, there is increased excitatory activity among limbic and paralimbic structures, as well as increased inhibition in the activity of dorsal cortical structures, by limbic structures in depression.
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
It is suggested that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect “hot wiring” networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target.
Depression, rumination and the default network.
Examination of connectivity of the default network specifically in the subgenual cingulate both on- and off-task revealed that MDDs show more neural functional connectivity between the posterior-cingulate cortex and the sub genual-cesulate cortex than healthy individuals during rest periods, but not during task engagement.
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
A goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD.
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Because the MPFC and related limbic structures provide forebrain modulation over visceral control structures in the hypothalamus and brainstem, their dysfunction can account for the disturbances in autonomic regulation and neuroendocrine responses that are associated with mood disorders.