Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation

  title={Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation},
  author={Sundeep Kalantry and Sonya Purushothaman and Randall Bryant Bowen and J. Starmer and Terry Magnuson},
XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation (XCI). XCI is an example of epigenetic regulation. Once enacted in individual cells of the early female embryo, XCI is stably transmitted such that most descendant cells maintain silencing of that X chromosome. In eutherian mammals, XCI is thought to be triggered by the expression of the non… CONTINUE READING
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A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

  • J Chaumeil, P Le Baccon, A Wutz, E. Heard
  • Genes Dev
  • 2006

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