Evidence of T cell receptor beta-chain patterns in inflammatory and noninflammatory bowel disease states.

@article{Saubermann1999EvidenceOT,
  title={Evidence of T cell receptor beta-chain patterns in inflammatory and noninflammatory bowel disease states.},
  author={Lawrence J. Saubermann and Christopher Sj Probert and Andreas D. Christ and Andreas Chott and Jerrold R Turner and A. Christopher Stevens and Steven P. Balk and R S Blumberg},
  journal={The American journal of physiology},
  year={1999},
  volume={276 3 Pt 1},
  pages={G613-21}
}
T cell activation, as defined by expression of relevant cell surface molecules, such as the interleukin-2 receptor (CD25), is increased in many chronic relapsing diseases, including inflammatory bowel disease (IBD). These T cells are generally activated through contact of their clonotypic T cell receptor (TCR) with a peptide antigen presented by a major histocompatibility complex molecule. One of the putative antigenic contact sites for the TCR is the third complementarity determining region… CONTINUE READING