Evidence of Plasma CoQ10‐Lowering Effect by HMG‐CoA Reductase Inhibitors: A Double‐Blind, Placebo‐Controlled Study

@article{Ghirlanda1993EvidenceOP,
  title={Evidence of Plasma CoQ10‐Lowering Effect by HMG‐CoA Reductase Inhibitors: A Double‐Blind, Placebo‐Controlled Study},
  author={G. Ghirlanda and A. Oradei and A. Manto and S. Lippa and L. Uccioli and S. Caputo and A. Greco and G. P. Littarru},
  journal={The Journal of Clinical Pharmacology},
  year={1993},
  volume={33}
}
  • G. Ghirlanda, A. Oradei, +5 authors G. P. Littarru
  • Published 1993
  • Medicine
  • The Journal of Clinical Pharmacology
  • Inhibitors of HMG‐CoA reductase are new safe and effective cholesterol‐lowering agents. Elevation of alanine‐amino transferase (ALT) and aspartate‐amino transferase (AST) has been described in a few cases and a myopathy with elevation of creatinine kinase (CK) has been reported rarely. The inhibition of HMG‐CoA reductase affects also the biosynthesis of ubiquinone (CoQ10). We studied two groups of five healthy volunteers treated with 20 mg/day of pravastatin (Squibb, Italy) or simvastatin (MSD… CONTINUE READING
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