Evidence of Gene Conversion in Genes Encoding the Gal/GalNac Lectin Complex of Entamoeba

@inproceedings{Weedall2011EvidenceOG,
  title={Evidence of Gene Conversion in Genes Encoding the Gal/GalNac Lectin Complex of Entamoeba},
  author={Gareth D. Weedall and James Sherrington and Steve Paterson and Neil Hall},
  booktitle={PLoS neglected tropical diseases},
  year={2011}
}
The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against amoebiasis. Acquired protective immunity raised against the lectin complex should create a selection pressure to change the amino acid sequence of lectin genes in order to avoid future detection. We… CONTINUE READING
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