Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

  title={Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors},
  author={Stefan Nickels and Th{\'e}r{\`e}se Truong and Rebecca Hein and Kristen L. Stevens and Katharina Buck and Sabine Behrens and Ursula Eilber and Martina Schmidt and Lothar Haeberle and Alina Vrieling and Mia M Gaudet and Jonine D Figueroa and Nils Schoof and Amanda B Spurdle and Anja Rudolph and Peter A. Fasching and John L. Hopper and Enes Makalic and Daniel F. Schmidt and Melissa C. Southey and Matthias W. Beckmann and Arif B. Ekici and Olivia Fletcher and Lorna Gibson and Isabel Dos Santos Silva and Julian Peto and Manjeet K. Humphreys and Jean Q Wang and Emilie Cordina-Duverger and Florence Menegaux and B\orge G. Nordestgaard and Stig E Bojesen and Charlotte Lanng and Hoda Anton-Culver and Argyrios Ziogas and Leslie Bernstein and Christina A. Clarke and Hermann Brenner and Heiko Mueller and Volker Arndt and Christa Stegmaier and Hiltrud Brauch and Thomas Br{\"u}ning and Volker Harth and The GENICA Network and Arto J Mannermaa and Vesa V. Kataja and Veli-Matti Kosma and Jaana M. Hartikainen and Kconfab and AOCS Management Group and Diether Lambrechts and Dominiek Smeets and Patrick Neven and Robert J. Paridaens and Dieter Flesch-Janys and Nadia Obi and Shan Wang-gohrke and Fergus J. Couch and Janet E. Olson and Celine M. Vachon and Graham G. Giles and Gianluca Severi and Laura Baglietto and Kenneth Offit and Esther M John and Alexander Miron and Irene L Andrulis and J. A. G. Knight and Gordon Glendon and Anna Marie Mulligan and Stephen J. Chanock and Jolanta Lissowska and Jianping Liu and Angela Cox and Helen E Cramp and Dan Connley and Sabapathy Balasubramanian and Alison M. Dunning and Mitul H. Shah and Amy Trentham-Dietz and Polly Newcomb and Linda J. Titus and Kathleen B Egan and Elizabeth K Cahoon and Preetha Rajaraman and Alice J. Sigurdson and Michele Morin Doody and Pascal Gu{\'e}nel and Paul P. D. Pharoah and Marjanka K. Schmidt and Per Hall and Doug F. Easton and Montserrat Garc{\'i}a-Closas and Roger L Milne and Jenny Chang-Claude},
  booktitle={PLoS genetics},
Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23… CONTINUE READING