Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

@article{Luca2004EvidenceOA,
  title={Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients},
  author={Vincenzo De Luca and Albert Hung Choy Wong and Daniel J. Muller and Gregory W H Wong and Rachel F. Tyndale and James L Kennedy},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1522-1526}
}
A number of studies have suggested that the α-7-nicotinic receptor D15S1360 polymorphism is associated with schizophrenia and a deficiency in the normal inhibition of the P50 auditory-evoked response. Schizophrenia patients and some of their unaffected relatives show a failure of inhibition in their 50-ms response to the second of a pair of tones. Biochemical studies have suggested that the α7 nicotinic acetylcholine receptor is involved in this sensory gating deficit. Furthermore, high-dose… CONTINUE READING