Evidence of 14C-Furazolidone Metabolite Binding to the Hepatic DNA of Trout

  title={Evidence of 14C-Furazolidone Metabolite Binding to the Hepatic DNA of Trout},
  author={J. Meng and S. Mangat and I. Grudzinski and F. Law},
  journal={Drug Metabolism and Drug Interactions},
  pages={209 - 220}
  • J. Meng, S. Mangat, +1 author F. Law
  • Published 1998
  • Chemistry, Medicine
  • Drug Metabolism and Drug Interactions
  • Furazolidone (FZ) is a nitrofuran drug commonly used in aquaculture. In the present study, [methylidene-14C]-FZ or [oxazolone-4,5-14C]-FZ was offered to rainbow trout (Oncorhyncus mykiss) in medicated feed at a daily dose of 135 mg/kg b. wt. for 10 days. The trout were sacrificed at specific time points post-dosing and the liver removed for DNA-bound 14C characterization. Both forms of the 14C-labelled FZ were converted by trout to reactive metabolite(s) which bound irreversibly to the hepatic… CONTINUE READING
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