Evidence in the mouse for self-renewing stem cells in the formation of a segmented longitudinal structure, the myotome.

@article{Nicolas1996EvidenceIT,
  title={Evidence in the mouse for self-renewing stem cells in the formation of a segmented longitudinal structure, the myotome.},
  author={Jean François Nicolas and Luc Mathis and Claire Bonnerot and W. Saurin},
  journal={Development},
  year={1996},
  volume={122 9},
  pages={2933-46}
}
A novel method of clonal analysis has been used in the mouse to define the cellular events that lead to the formation of a segmented longitudinal structure, the myotome. Progenitor cells of the myotome were randomly marked during development by intragenic homologous recombination in transgenic mice expressing a reporter laacZ gene. 153 clones corresponding to 7829 cells, that is 20% of the myotomal population of one embryo, were obtained from 3000 E11.5 embryos. Their analysis leads to the… CONTINUE READING

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