Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code

@article{Bernhardt2008EvidenceFG,
  title={Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code},
  author={Harold S. Bernhardt and Warren P. Tate},
  journal={Biology Direct},
  year={2008},
  volume={3},
  pages={53 - 53}
}
Transfer RNA (tRNA) is the means by which the cell translates DNA sequence into protein according to the rules of the genetic code. A credible proposition is that tRNA was formed from the duplication of an RNA hairpin half the length of the contemporary tRNA molecule, with the point at which the hairpins were joined marked by the canonical intron insertion position found today within tRNA genes. If these hairpins possessed a 3'-CCA terminus with different combinations of stem nucleotides (the… CONTINUE READING
12 Citations
54 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 54 references

On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization

  • YI Wolf, EV Koonin
  • Biol Direct 2007,
  • 2007
Highly Influential
4 Excerpts

Atomic determinants for aminoacylation of RNA minihelices and relationship to genetic code

  • K Musier-Forsyth, P Schimmel
  • Acc Chem Res
  • 1999
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…