Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart.

@article{Tauskela1999EvidenceFC,
  title={Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart.},
  author={Joseph S. Tauskela and Balu R Chakravarthy and Carol L. Murray and Yun Wang and Tanya Comas and Michael T Hogan and Antoine Hakim and P. D. Morley},
  journal={Brain research},
  year={1999},
  volume={827 1-2},
  pages={
          143-51
        }
}
Ca2+ influx and activation of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) during nonlethal ischemic preconditioning have been implicated in the protection of the heart against subsequent lethal ischemic injury. Thus, we determined if Ca2+ influx, PKC and MAPK also mediate ischemic preconditioning-induced protection in neurons. Preconditioning by exposure of E18 rat cortical cultures to 90 min of nonlethal oxygen-glucose deprivation (OGD) 24 h prior to 180-240 min of… CONTINUE READING

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