Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes.

@article{Li1999EvidenceFA,
  title={Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes.},
  author={Shaohua Li and Stephen Michael Sims and Yun Jiao and Lawrence Chow and J. Geoffrey Pickering},
  journal={Circulation research},
  year={1999},
  volume={85 4},
  pages={338-48}
}
Smooth muscle cells (SMCs) perform diverse functions that can be categorized as contractile and synthetic. A traditional model holds that these distinct functions are performed by the same cell, by virtue of its capacity for bidirectional modulation of phenotype. However, this model has been challenged, in part because there is no physiological evidence that an adult synthetic SMC can acquire the ability to contract. We sought evidence for this by cloning adult SMCs from human internal thoracic… CONTINUE READING

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