Evidence for widespread positive and purifying selection across the European rabbit (Oryctolagus cuniculus) genome.

@article{Carneiro2012EvidenceFW,
  title={Evidence for widespread positive and purifying selection across the European rabbit (Oryctolagus cuniculus) genome.},
  author={Miguel Ara{\'u}jo Carneiro and Frank Wolfgang Albert and Jos{\'e} Melo-Ferreira and Nicolas Galtier and Philippe Gayral and Jos{\'e} Antonio Blanco-Aguiar and R. M. Villafuerte and Michael W Nachman and Nuno Ferrand},
  journal={Molecular biology and evolution},
  year={2012},
  volume={29 7},
  pages={1837-49}
}
The nearly neutral theory of molecular evolution predicts that the efficacy of both positive and purifying selection is a function of the long-term effective population size (N(e)) of a species. Under this theory, the efficacy of natural selection should increase with N(e). Here, we tested this simple prediction by surveying ~1.5 to 1.8 Mb of protein coding sequence in the two subspecies of the European rabbit (Oryctolagus cuniculus algirus and O. c. cuniculus), a mammal species characterized… CONTINUE READING