Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy.

@article{Mooij2000EvidenceFV,
  title={Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy.},
  author={Petra Mooij and Willy M. J. M. Bogers and Herman Oostermeijer and Wim H Koornstra and Peter J F Ten Haaft and Babs E. Verstrepen and Gert Van der Auwera and Jonathan Luke Heeney},
  journal={Journal of virology},
  year={2000},
  volume={74 9},
  pages={4017-27}
}
Current strategies in human immunodeficiency virus type 1 (HIV-1) vaccine development are often based on the production of different vaccine antigens according to particular genetic clades of HIV-1 variants. To determine if virus virulence or genetic distance had a greater impact on HIV-1 vaccine efficacy, we designed a series of heterologous chimeric simian/human immunodeficiency virus (SHIV) challenge experiments in HIV-1 subunit-vaccinated rhesus macaques. Of a total of 22 animals, 10… CONTINUE READING