Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques.

@article{Kong2005EvidenceFV,
  title={Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques.},
  author={Yao-zhong Kong and Xiao-ru Huang and Xiaosen Ouyang and J Tan and Guenter Fingerle-Rowson and Michael Bacher and Wei Mu and Larry A Scher and Lin Leng and Richard Bucala and Hui Y Lan},
  journal={Cardiovascular research},
  year={2005},
  volume={65 1},
  pages={272-82}
}
OBJECTIVE Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and has been shown to play a role in pathogenesis of atherosclerosis. The aim of this study is to investigate the potential role of MIF in the destabilization of atherosclerotic plaques by stimulation of vascular MMP-1 expression. METHODS MIF and matrix metalloproteinase protein-1 (MMP-1) expression in human atherosclerotic plaques were determined by immunohistochemistry. The functional activity of MIF was… CONTINUE READING