Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter

@article{Wlfel2004EvidenceFV,
  title={Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter},
  author={Reinhard W{\"o}lfel and Karl Heinz Graefe},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={345},
  pages={129-136}
}
  • R. Wölfel, K. Graefe
  • Published 1 February 1992
  • Biology
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryThe aim of the present study was to answer the question whether amines other than 5-hydroxytryptamine (5-HT) and tryptamine act as substrates of the platelet 5-HT transporter. To this end, a large number of tryptamines, 5-HT receptor agonists and phenethylamines (which had IC50 values for 3H-5-HT uptake inhibition of 145–24500 nmol l−1) was examined in rabbit platelets in order to determine their ability to induce an outward transport of 3H-5-HT Platelets (the MAO of which was blocked… 
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It is concluded that tryptamines that are more effective in releasing 3H-5-HT than imipramine have the property of being substrates of the 5-HT transporter.
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