Evidence for two types of cytotoxic necrotizing factor in human and animal clinical isolates of Escherichia coli.

@article{Rycke1990EvidenceFT,
  title={Evidence for two types of cytotoxic necrotizing factor in human and animal clinical isolates of Escherichia coli.},
  author={Jean De Rycke and Enrique A Gonz{\'a}lez and Jorge Blanco and E. T. Oswald and M Victoria Blanco and Robert Boivin},
  journal={Journal of clinical microbiology},
  year={1990},
  volume={28 4},
  pages={694-9}
}
We have characterized the in vitro and in vivo toxic properties of cell sonic extracts from 22 animal and human clinical isolates of Escherichia coli that caused both necrosis in the rabbit skin and multinucleation in tissue cultures, two toxic properties previously reported as being specific for E. coli cytotoxic necrotizing factor (CNF). Two distinct toxic phenotypes were observed. Type 1, which was displayed by originally described CNF strains, was characterized by extensive multinucleation… CONTINUE READING

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