Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.

@article{Cobb2010EvidenceFT,
  title={Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.},
  author={Joanna E. Cobb and Sophie G. Zaloumis and Katrina Jacqueline Scurrah and Stephen Brian Harrap and Justine A. Ellis},
  journal={Experimental dermatology},
  year={2010},
  volume={19 11},
  pages={1026-8}
}
The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia - AGA). In case-control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA (P = 3.75 × 10(-5)) in 1195 men. We also replicated association with a recently… CONTINUE READING

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