Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals.

@article{Felip2009EvidenceFT,
  title={Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals.},
  author={A Felip and Silvia Zanuy and Rafael Pineda and Leonor Pinilla and Manuel Carrillo and Manuel Tena-Sempere and Ana Gomez},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={312 1-2},
  pages={61-71}
}
Kisspeptins, the products of KiSS-1 gene, have recently emerged as fundamental regulators of reproductive function in different mammalian and, presumably, non-mammalian species. To date, a single form of KiSS-1 has been described in mammals, and recently, in several fish species and Xenopus. We report herein the cloning and characterization of two distinct KiSS-like genes, namely, KiSS-1 and KiSS-2, in the teleost sea bass. While KiSS-1 encodes a peptide identical to rodent kisspeptin-10, the… CONTINUE READING
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