Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.

@article{Li1996EvidenceFT,
  title={Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.},
  author={Gang Li and Jianlin Feng and Lixia Yue and Michel Carrier and Stanley Nattel},
  journal={Circulation research},
  year={1996},
  volume={78 4},
  pages={
          689-96
        }
}
Previous voltage-clamp studies have suggested that the delayed rectifier current (IK) is small or absent in the human ventricle and, when present, consists only of the rapid component (IKr); however, molecular studies suggest the presence of functionally important IK in the human heart, specific IKr blockers are known to delay ventricular repolarization and cause the long QT syndrome in humans, and we have shown that the expression of IK is strongly influenced by cell isolation techniques. The… CONTINUE READING

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